| No. | Author | Title | Reference | ES Cell Lines | ES Core |
| 1. | Maclvor, D. et al | Normal Neutrophil Function in Cathepsin G-Deficient Mice | Blood, Vol. 94, (12): pp. 4282 - 4293, December 15, 1999 | ||
| 2. | Kaufman, R. et al | Transgenic Analysis of a 100-kb Human B-Globin Cluster-Containing DNA Fragment Propagated as a Bacterial Artificial Chromosome | Blood, Vol. 94, (9): pp. 3178 - 3184, November 1, 1999 | ||
| 3. | Pham, C. et al | Dipeptidyl Peptidase I is Required for the Processing and of Granzymes A and B in vitro | Proc. Natl. Acad. Sci. USA, Vol. 96: pp. 8627 - 8632, July, 1999 | ||
| 4. | Shresta, S. et al | Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis | Immunity, Vol. 10, 595 - 605, May, 1999 | ||
| 5. | Belaaouaj, A., et al | Mice Lacking Neutrophil Elastase Reveal Impaired Host Defense Against Gram Negative Bacterial Sepsis | Nature Medicine, Vol. 4, (5): May, 1998 | ||
| 6. | Abbott, R. et al | Augmented Inflammatory Responses and Altered Wound Healing in Cathepsin-G Deficient Mice | ARCH Surg., Vol. 133, September, 1998 | ||
| 7. | Shresta, S. et al | Residual Cytotoxicity and Granzyme K Expression in Granzyme A-Deficient Cytotoxic Lymphocytes | The Journal of Biological Chemistry, Vol. 272, No. 32, pp. 20236 - 20244, August 8, 1997 | ||
| 8. | Hug, B. et al | Analysis of Mice Containing a Targeted Deletion of B-Globin Locus Control Region 5' Hypersensitive Site 3 | Molecular and Cellular Biology, Vol. 16, (6): pp. 2906 - 2912, 3 June, 1996 | ||
| 9. | Shih, N. et al | Congenital Nephrotic syndrome in Mice Lacking CD2-Associated Protein | Science, Vol. 286 (5438), pp. 312 - 315, October 8, 1999 | ||
| 10. | Shirasawa, S. et al | Enx (Hox11L1)-Deficient Mice Develop Myenteric Neuronal Hyperplasia and Megacolon | Nature Medicine, Vol. 3, (6): June, 1997 | ||
| 11. | Liu, F., et al | Impaired Production and Increased Apoptosis of Neutrophils in Granulocyte Colony-Stimulating Factor Receptor-Deficient Mice | Immunity, Vol. 5, pp. 491 - 501, November, 1996 | ||
| 12. | Knudson, C., et al | Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death | Science, Vol. 270, pp. 96 - 99, October 6, 1995 | ||
| 13. | Sadovsky, Y. et al | Mice Deficient in the Orphan Receptor Steroidogenic Factor 1 Lack Adrenal Glands and Gonads but Express P450 Side-Chain-Cleavage Enzyme in the Placenta and Have Normal Embryonic Serum Levels of Corticosteroids | Proc. Natl. Acad. Sci. USA, Vol. 92, pp. 10939 - 10943, November, 1995 | ||
| 14. | Shipley, J., et al | Metalloelastase is Required for Macrophage-Mediated Proteolysis and Matrix Invasion in Mice | Proc. Natl. Acad. Sci. USA, Vol. 93, pp. 3942 - 3946, April, 1996 | ||
| 15. | McLemore, M., et al | Increased Granulocyte Colony-Stimulating Factor Responsiveness but Normal Resting Granulopoiesis in Mice Carrying a Targeted Granulocyte Colony-Stimulating Factor Receptor Mutation Derived from a Patient with Severe Congenital Neutropenia | Journal of Clinical Investigation, Vol. 120 (3), pp. 483 - 492, August 1, 1998 | ||
| 16. | Liu, F. et al | Interleukin-6 and the Granulocyte Colony-Stimulating Factor Receptor are Major Independent Regulators of Granulopoiesis in vivo but are not Required for Lineage Commitment or Terminal Differentiation | Blood, Vol. 90, (7): pp. 2583 - 2590 October 1, 1997 | ||
| 17. | Liu, F. et al | The Granulocyte Colony-Stimulating Factor Receptor is Required for the Mobilization of Murine Hematopoietic Progenitors into Peripheral Blood by Cyclophosphamide or Interleukin-8 but not Flt-3 Ligand | Blood, Vol. 90, (7): pp.2522 - 2528, October 1, 1997 | ||
| 18. | Semerad, C. et al | A Role for G-CSF Receptor Signaling in the Regulation of Hematopoietic Cell Function but not Lineage Commitment of Differentiation | Immunity Vol. 11, (2): pp. 153 - 161, August, 1999 | ||
| 19. | Rinkenberger, J., et al | Mcl-1 Deficiency Results in Pre-Implantation Embryonic Lethality | Genes & Development, Vol. 14, (1): pp. 23 - 27, January, 2000 | ||
| 20. | Yin, X-M. et al | Bid-Deficient Mice are Resistant to Fas-Induced Hepatocellular Apoptosis | Nature, Vol. 400, (26): August, 1999 | ||
| 21. | Crawford, P., et al | Nuclear Receptor Steroidogenic Factor 1 Directs Embryonic Stem Cells Toward the Steroidgenic Lineage | Molecular and Cellular Biology, Vol. 17, (7): pp. 3997 - 4006, July, 1997 | ||
| 23. | Enomoto, H., et al | GFRa1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys | Neuron, Vol. 21, pp. 317 - 324, August, 1998 | ||
| 24. | Heuckeroth, R., et al | Gene Targeting Reveals a Critical Role for Neuturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons | Neuron, Vol. 22, pp. 253 - 263, February, 1999 | ||
| 33. | Edelstein, C., et al | Macrophage Metalloelastase, MMP-12, Cleaves Human Apolipoprotein (a) in the Linker Region Between Kringles IV-4 and IV-5: Potential Relevance to Lipoprotein (a) Biology | Journal of Biological Chemistry, Vol. 274, pp. 10019 - 10023, 1999 | ||
| 36. | Huppert, S., et al | Embryonic Lethality in Mice Homozygous for a Processing Deficient Notch 1 Allele | Nature, Vol. 405, pp. 966 - 970, June 22, 2000 | ||
| 37. | Huang, Z., et al | Tissue Factor Pathway Inhibitor Gene Disruption Produces Intrauterine Lethality in Mice | Blood, Vol. 90, (3): pp. 944 - 951, August 1, 1997 | ||
| 38. | Barton, K., et al | The Ets-1 Transcription Factor is Required for the Development of Natural Killer Cells in Mice | Immunity, Vol. 9, pp. 555 - 563, October, 1998 | ||
| 39. | Toomey, J., et al | Effect of Tissue Factor Deficiency on Mouse and Tumor Development | Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 6922 - 6926, June, 1997 | ||
| 40. | Threadgill, D., et al | Genealogy of the 129 Inbred Strains: 129/SvJ is a Contaminated Inbred Strain | Mammalian Genome Vol. 8, pp. 390 - 393, 1997 | ||
| 42. | Simpson, E., et al | Genetic Variation Among 129 Substrains and its Importance for Targeted Mutagenesis in Mice | Nature Genetics, Vol. 16, pp. 19 - 27, May, 1997 | ||
| 43. | Shipley, J., et al | Developmental Expression of Latent TGF-B Binding Protein-2 and its Requirement Early in Mouse Development | Molecular and Cellular Biology, Vol. 20 (13): pp. 4879 - 4887, July, 2000 | ||
| 44. | Yin, Z., et al | Prothrombotic Phenotype of Protein Z Deficiency | Proc. Natl. Acad. Sci. USA, Vol. 97, (12): pp. 6734 - 6738, June 6, 2000 | ||
| 46. | Brody, S., et al | Ciliogenesis and Left-Right Axis Defects in Forkhead Factor HFH-4-Null Mice | American Journal of Respiratory Cellular Molecular Biology, Vol. 23, pp. 45 - 51, July 1, 2000 | ||
| 47. | Shirasawa, S., et al | Rnx Deficiency Results in Congenital Central Hypoventilation | Nature Genetics, Vol. 24 (3): pp. 287 - 290, March, 2000 | ||
| 48. | Hurov, Jonathan B., et al | Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk1 (Par-1) Protein Kinase | Molecular and Cellular Biology, Vol. 21 (9): pp. 3206 - 3219, May, 2001 | ||
| 49. | Chen, M-S., et al | Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase | Molecular and Cellular Biology, Vol. 21 (12): pp. 3853 - 3861, June, 2001 | ||
| 50. | McLemore, M., et al | STAT-3 Activation is Required for Normal G-CSF Dependent Proliferation and Granulocytic Differentiation | Immunity, Vol. 14, pp. 193 - 204, February, 2001 | ||
| 51. | Ho, N. et al | Impaired Synaptic Plasticity and cAMP Response Element-binding Protein Activation in Ca2+/Calmodulin-dependent Protein Kinase Type IV/Gr-deficient Mice | Journal of Neuroscience, Vol. 20 (17), pp. 6459 - 72, September 1, 2000 | ||
| 52. | Liu, Z., et al | Coordination of Chondrogenesis and Osteogenesis by Fibroblast Growth Factor 18 | Genes and Development, Vol. 16 (7), pp. 859 - 869, April 1, 2002 | ||
| 53. | Chen, Z., et al | A Targeted Apolipoprotein B-38.9-producing Mutation Causes Fatty Livers in Mice Due to the Reduced Ability of Apolipoprotein B-38.9 to Transport Triglycerides | Journal of Biological Chemistry, Vol. 275, No. 42, pp. 32807 - 32815, October 20, 2000 | ||
| 54. | Li, H., et al | Heparin Cofactor II Inhibits Arterial Thrombosis After Endothelial Injury | Journal of Clinical Investigation, Vol. 109, pp. 213 - 219, 2001 | ||
| 55. | Chen, Z., et al | Hypobetalipoproteinemic Mice with a Targeted Apolipoprotein (Apo) B-27.6-specifying Mutation | Journal of Biological Chemistry, Vol. 277, No. 16, pp. 14135 - 14145, April 19, 2002 | ||
| 56. | Circolo, A., et al | Genetic Disruption of the Murine Complement C3 Promoter Region Generates Dificient Mice with Extrahepatic Expression of C3 mRNA | Immunopharmacology, Vol. 42, pp. 135 - 149, 1999 | ||
| 57. | Shih. D.M., et al | Mice Lacking Serum Paraoxonase are Susceptible to Organophosphate Toxicity and Atherosclerosis | Nature, Vol. 394, pp. 284 - 287, July 16, 1998 | ||
| 58. | Sakai, N., et al | Targeted Disruption of the Mouse Lecithin: Cholesterol Acyltransferase (LCAT) Gene | Journal of Biological Chemistry, Vol. 272, No. 11, pp. 75-6 - 7510, March 14, 1997 | ||
| 59. | Korhonen, V., et al | Spermine Deficiency Resulting from Targeted Disruption of the Spermine Synthase Gene in Embryonic Stem Cells Leads to Enhanced Sensitivity to Antiproliferative Drugs | Molecular Pharmacology, Vol. 59, No. 2, pp. 231 - 238, 2001 | ||
| 60. | Esteban, L.M., et al | Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development | Molecular and Cellular Biology, Vol. 21, No. 5, pp. 1444 - 1452, 2001 | ||
| 61. | Kaufman, R.M., et al | Lack of Neighborhood Effects From a Transcriptionally Active Phosphoglycerate Kinase-neo Cassette Located Between the Murine B-major and B-minor Globin Genes | Blood, Vol. 98, No. 1, pp. 65 - 73, July 1, 2001 | ||
| 62. | D'Agostino, D., et al | Decreased Postnatal Survival and Altered Body Weight Regulation in Procolipase-deficient Mice | Journal of Biological Chemistry, Vol. 277, No. 9, pp. 7170 - 7177, March 1, 2002 | ||
| 63. | Lagutina, I., et al | Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors | Molecular and Cellular Biology, Vol. 22, No. 20, pp. 7204 - 7216, 2002 | ||
| 64. | Yu, K., et al | Conditional Inactivation of FGF Receptor 2 Reveals an Essential Role for FGF Signaling in the Regulation of Osteoblast Function and Bone Growth | Development, Vol. 130, pp. 3063 - 3074, 2003 | ||
| 66. | Coste, S.C., et al | Abnormal Adaptations to Stress and Impaired Cardiovascular Function in Mice Lacking Corticotropin-releasing Hormone Receptor-2 | Nature Genetics, Vol. 24, pp. 403 - 409, April, 2000 | ||
| 67. | He, J., et al | Targeted Disruption of Dkc1, the Gene Mutated in X-linked Dyskeratosis Congenita, Causes Embryonic Lethality in Mice | Oncogene, Vol. 21, pp. 7740 - 7744, 2002 | ||
| 68. | Lu, Z.H., et al | Long Targeting Arms Do Not Increase the Efficiency of Homologous Recombination in the B-globin Locus of Murine Embryonic Stem Cells | Blood, Vol. 102, No. 4, pp. 1531 - 1533, August 15, 2003 | ||
| 69. | Niiranen, K., et al | Targeted Disruption of spermidine/Spermine N1-Acetyltransferase Gene in Mouse Embryonic Stem Cells: Effects on Polyamine Homeostasis and Sensitivity to Polyamine Analogues | Journal of Biological Chemistry, Vol. 277, No. 28, pp. 25323 - 25328, July 12, 2002 | ||
| 70. | Kiefer, S.M., et | Expression of a Truncated Sall 1 Transcriptional Repressor is Responsible for Townes-Brocks Syndrome Birth Defects | Human Molecular Genetics, Vol. 12, No. 17, pp. 2221 - 2227, 2003 | ||
| 71. | Ranger, A.M., et al | Bad-deficient Mice Develop Diffuse Large B Cell Lymphoma | Proc. Natl. Acad. Sci. USA, Vol. 100, No. 16, pp. 9324 - 9329, August 5, 2003 | ||
| 72. | Crestani, F., et al | Trace Fear Conditioning Involves Hippocampal alpha5 GABAA Receptors | Proc. Natl. Acad. Sci. USA, Vol. 99, No. 13, pp. 8980 - 8985, June 25, 2002 | ||
| 73. | Enomoto, H., et al | RET Signaling is Essential for Migration, Axonal Growth and Axon Guidance of Developing Sympathetic Neurons | Development, Vol. 128, pp. 3963 - 3974, 2001 | ||
| 74. | Ivkovic, S., et al | Connective Tissue Growth Factor Coordinates Chondrogenesis and Angiogenesis During Skeletal Development | Development, Vol. 130, pp. 2779 - 2791, 2003 | ||
| 75. | Narducci, M. G., et al | TCL1 Participates in Early Embryonic Development and is Overexpressed in Human Seminomas | Proc. Natl. Acad. Sci. USA, Vol. 99, No. 18, pp. 11712 - 11717, September 3, 2002 | ||
| 76. | Brown, L.J., et al | Normal Thyroid Thermogenesis but Reduced Viability and Adiposity in Mice Lacking the Mitochondrial Glycerol Phosphate Dehydrogenase | Journal of Biological Chemistry, Vol. 277, No. 36, pp. 32892 - 32898, 2002 | ||
| 77. | Rokosh, D.G., et al | Knockout of the alpha1A/C-adrenergic Receptor Subtype: The alpha1A/C is Expressed in Resistance Arteries and is Required to Maintain Arterial Blood Pressure | Proc. Natl. Acad. Sci. USA, Vol. 99, No. 14, pp. 9474 - 9479, July 9, 2002 | ||
| 78. | Luo, Y., et al | Mice Deficient in BACE1, the Alzheimer's Beta-secretase, have Normal Phenotype and Abolished Beta-amyloid Generation | Nature Neuroscience, Vol. 4, No. 3, pp. 231 - 232, March, 2001 | ||
| 79. | Zhang, N., et al | A Dominant-negative Pleiotrophin Mutant Introduced by Homologous Recombination Leads to Germ-cell Apoptosis in Male Mice | Proc. Natl. Acad. Sci. USA, Vol. 96, pp. 6734 - 6738, June, 1999 | ||
| 80. | Westervelt, R., et al | High-penetrance Mouse Model of Acute Promyelocytic Leukemia with Very Low Levels of PML-RARalpha Expression | Blood, Vol. 102, No. 5, pp. 1857 - 1865, September 1, 2003 | ||
| 81. | Grenda, D.S., et al | Mice Expressing a Neutrophil Elastase Mutation Derived from Patients with Severe Congenital Neutropenia Have Normal Granulopoiesis | Blood, Vol. 100, No. 9, pp. 3221 - 3228, November 1, 2002 | ||
| 82. | Newberry, E.P., et al | Decreased Hepatic Triglyceride Accumulation and Altered Fatty Acid Uptake in Mice with Deletion of the Liver Fatty Acid-binding Protein Gene | Journal of Biological Chemistry , Vol. 278, No. 51, pp. 51664 - 51672, December 19, 2003 | ||
| 83. | Shapiro, S.D., et al | Neutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in Mice | American Journal of Pathology, Vol. 163, No. 6, pp.2329 - 2335, December, 2003 | ||
| 84. | Blaeser, F., et al | Targeted Inactivation of the IL-4 Receptor alpha Chain I4R Motif Promotes Allergic Airway Inflammation | Journal of Experimental Medicine , Vol. 198, No. 8, pp. 1189 - 1200, October 20, 2003 | ||
| 85. | Fenske, T.S., et al | Stem Cell Expression of the AML1/ETO Fusion Protein Induces a Myeloproliferative Disorder in Mice | Proc. Natl. Acad. Sci. USA , Vol. 101, No. 42, pp. 15184 - 15189, October 29, 2004 | ||
| 86. | Krempler, A., et al | Generation of a Conditional Knockout Allele for the Janus Kinase 2 (Jak2) Gene in Mice | Genesis, Vol. 40, pp. 52 - 57, June 4, 2004 | ||
| 87. | Yang, X., et al | Notch Activation Induces Apoptosis in Neural Progenitor Cells Through a p53-Dependent Pathway | Developmental Biology , Vol. 269, pp. 81 - 94, January 14, 2004 | ||
| 88. | Ondr, J.K., et al | Characterization of Murine Cathepsin W and Its Role in Cell-Mediated Cytotoxicity | Journal of Biological Chemistry , Vol. 279, No. 26, pp. 27525 - 27533, June 25, 2004 | ||
| 89. | Hadland, B. K., et al | A Requirement for Notch 1 Distinguishes 2 Phases of Definitive Hematopoieses During Development | Blood, Vol. 104, No. 10, pp. 3097 - 3105, November 15, 2004 | ||
| 90. | Revell, P.A., et al | Granzyme B and the Downstream Granzymes C and/or F are Important for Cytotoxic Lymphocyte Functions | Journal of Immunology , Vol. 174, No. 4, pp. 2124-2131, February 15, 2005 | ||
| 91. | Leone, T. C., et al | PGC-1alpha Deficiency Causes Multi-system Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis | PLoS Biology , Vol. 3, No. 4, pp. 0672-March 15, 2005 | ||
| 92. | Lu, Z. H., et al | YB-1 is Important for Lte-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence | Molecular and Cellular Biology , Vol. 25, No. 11, pp. 4625-4637, June, 2005 | ||
| 93. | Lin, W., et al | Allergic Dysregulation and Hyperimmunoglobulinemia E in Foxp3 Mutant Mice | Journal of Allergy and Clinical Immunology, Vol. 116, No. 5, pp. 1106- 1115, November, 2005 | ||
| 94. | Lu, Z., et al | Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions During Murine Embryogenesis | Molecular and Cellular Biology , Vol. 26., No. 22, pp. 8410 - 8417, November 2006 | ||
| 95. | Wang, Y., et al | Epimorphin -/- Mice Have Increased Intestinal Growth, Decreased Susceptibility to Dextran Sodium Sulfate Colitis, and Impaired Spermatogenesis | Journal of Clinical Investigation , Vol. 116, No. 6, pp. 1535-1546, June, 2006 | ||
| 96. | Friend, L.D., et al | A Dose-dependent Requirement for the Proline Motif of CD28 in Cellular and Humoral Immunity Revealed by a Targeted Knockin Mutant | Journal of Experimental Medicine , Vol. 203, No. 9, pp. 2121-2133, September 4, 2006 | ||
| 97. | Xu, J., et al | Normal Lung Development in RAIG1-Deficient Mice Despite Unique Lung Epithelium-Specific Expression | American Journal of Respiratory Cell and Molecular Biology , Vol.32, pp.381-387, January 27, 2005 | ||
| 98. | Blaeser, F., et al | Long Term Memory Deficits in Pavlovian Fear Conditioning in CaMKK-alpha Deficient Mice | Molecular and Cellular Biology, Vol. 26., No. 23, pp. 9105 - 9115, December, 2006 | ||
| 99. | Krishnamurthy, K., et al | Ceramide Regulate Atypical PKCz/l-mediated Cell Polarity in Primitive Ectoderm Cells: A Novel Function of Sphingolipids in Morphogenesis | Journal of Biological Chemistry, Vol. 282, No. 5, pp. 3379-3390, February 2, 2007 | ||
| 100. | Lin, W., et al | Regulatory T Cell Development in the Absence of Functional Foxp3 | Nature Immunology, (corrected online) February 18, 2007 | ||
| 101. | Haribhai, D., et al | Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen | Journal of Immunology, Vol. 178, No. 5, pp. 2961-2972, March 1, 2007 |