No.AuthorTitleReferenceES Cell LinesES Core
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3.Pham, C. et alDipeptidyl Peptidase I is Required for the Processing and of Granzymes A and B in vitro Proc. Natl. Acad. Sci. USA,
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5.Belaaouaj, A., et alMice Lacking Neutrophil Elastase Reveal Impaired Host Defense Against Gram Negative Bacterial SepsisNature Medicine,
Vol. 4, (5): May, 1998
6.Abbott, R. et alAugmented Inflammatory Responses and Altered Wound Healing in Cathepsin-G Deficient MiceARCH Surg.,
Vol. 133, September, 1998
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Vol. 272, No. 32, pp. 20236 - 20244, August 8, 1997
8.Hug, B. et alAnalysis of Mice Containing a Targeted Deletion of B-Globin Locus Control Region 5' Hypersensitive Site 3Molecular and Cellular Biology,
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9.Shih, N. et alCongenital Nephrotic syndrome in Mice Lacking CD2-Associated ProteinScience,
Vol. 286 (5438), pp. 312 - 315, October 8, 1999
10.Shirasawa, S. et alEnx (Hox11L1)-Deficient Mice Develop Myenteric Neuronal Hyperplasia and MegacolonNature Medicine,
Vol. 3, (6): June, 1997
11.Liu, F., et alImpaired Production and Increased Apoptosis of Neutrophils in Granulocyte Colony-Stimulating Factor Receptor-Deficient MiceImmunity,
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12.Knudson, C., et alBax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell DeathScience,
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13.Sadovsky, Y. et alMice Deficient in the Orphan Receptor Steroidogenic Factor 1 Lack Adrenal Glands and Gonads but Express P450 Side-Chain-Cleavage Enzyme in the Placenta and Have Normal Embryonic Serum Levels of CorticosteroidsProc. Natl. Acad. Sci. USA,
Vol. 92, pp. 10939 - 10943, November, 1995
14.Shipley, J., et alMetalloelastase is Required for Macrophage-Mediated Proteolysis and Matrix Invasion in MiceProc. Natl. Acad. Sci. USA,
Vol. 93, pp. 3942 - 3946, April, 1996
15.McLemore, M., et alIncreased Granulocyte Colony-Stimulating Factor Responsiveness but Normal Resting Granulopoiesis in Mice Carrying a Targeted Granulocyte Colony-Stimulating Factor Receptor Mutation Derived from a Patient with Severe Congenital NeutropeniaJournal of Clinical Investigation,
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16.Liu, F. et alInterleukin-6 and the Granulocyte Colony-Stimulating Factor Receptor are Major Independent Regulators of Granulopoiesis in vivo but are not Required for Lineage Commitment or Terminal DifferentiationBlood,
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17.Liu, F. et alThe Granulocyte Colony-Stimulating Factor Receptor is Required for the Mobilization of Murine Hematopoietic Progenitors into Peripheral Blood by Cyclophosphamide or Interleukin-8 but not Flt-3 LigandBlood,
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18.Semerad, C. et alA Role for G-CSF Receptor Signaling in the Regulation of Hematopoietic Cell Function but not Lineage Commitment of Differentiation Immunity Vol. 11, (2): pp. 153 - 161, August, 1999
19.Rinkenberger, J., et alMcl-1 Deficiency Results in Pre-Implantation Embryonic LethalityGenes & Development,
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20.Yin, X-M. et alBid-Deficient Mice are Resistant to Fas-Induced Hepatocellular ApoptosisNature,
Vol. 400, (26): August, 1999
21.Crawford, P., et alNuclear Receptor Steroidogenic Factor 1 Directs Embryonic Stem Cells Toward the Steroidgenic LineageMolecular and Cellular Biology,
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23.Enomoto, H., et alGFRa1-Deficient Mice Have Deficits in the Enteric Nervous System and KidneysNeuron,
Vol. 21, pp. 317 - 324, August, 1998
24.Heuckeroth, R., et alGene Targeting Reveals a Critical Role for Neuturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic NeuronsNeuron,
Vol. 22, pp. 253 - 263, February, 1999
33.Edelstein, C., et alMacrophage Metalloelastase, MMP-12, Cleaves Human Apolipoprotein (a) in the Linker Region Between Kringles IV-4 and IV-5: Potential Relevance to Lipoprotein (a) BiologyJournal of Biological Chemistry,
Vol. 274, pp. 10019 - 10023, 1999
36.Huppert, S., et alEmbryonic Lethality in Mice Homozygous for a Processing Deficient Notch 1 AlleleNature,
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37.Huang, Z., et alTissue Factor Pathway Inhibitor Gene Disruption Produces Intrauterine Lethality in MiceBlood,
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38.Barton, K., et alThe Ets-1 Transcription Factor is Required for the Development of Natural Killer Cells in MiceImmunity,
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39.Toomey, J., et alEffect of Tissue Factor Deficiency on Mouse and Tumor DevelopmentProc. Natl. Acad. Sci. USA,
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40.Threadgill, D., et alGenealogy of the 129 Inbred Strains: 129/SvJ is a Contaminated Inbred StrainMammalian Genome Vol. 8, pp. 390 - 393, 1997
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43.Shipley, J., et alDevelopmental Expression of Latent TGF-B Binding Protein-2 and its Requirement Early in Mouse DevelopmentMolecular and Cellular Biology,
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44.Yin, Z., et alProthrombotic Phenotype of Protein Z DeficiencyProc. Natl. Acad. Sci. USA,
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46.Brody, S., et alCiliogenesis and Left-Right Axis Defects in Forkhead Factor HFH-4-Null MiceAmerican Journal of Respiratory Cellular Molecular Biology,
Vol. 23, pp. 45 - 51, July 1, 2000
47.Shirasawa, S., et alRnx Deficiency Results in Congenital Central HypoventilationNature Genetics,
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48.Hurov, Jonathan B., et alImmune System Dysfunction and Autoimmune Disease in Mice Lacking Emk1 (Par-1) Protein KinaseMolecular and Cellular Biology,
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49.Chen, M-S., et alAbsence of Apparent Phenotype in Mice Lacking Cdc25C Protein PhosphataseMolecular and Cellular Biology,
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50.McLemore, M., et alSTAT-3 Activation is Required for Normal G-CSF Dependent Proliferation and Granulocytic DifferentiationImmunity,
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51.Ho, N. et alImpaired Synaptic Plasticity and cAMP Response Element-binding Protein Activation in Ca2+/Calmodulin-dependent Protein Kinase Type IV/Gr-deficient MiceJournal of Neuroscience,
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52.Liu, Z., et alCoordination of Chondrogenesis and Osteogenesis by Fibroblast Growth Factor 18Genes and Development,
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53.Chen, Z., et alA Targeted Apolipoprotein B-38.9-producing Mutation Causes Fatty Livers in Mice Due to the Reduced Ability of Apolipoprotein B-38.9 to Transport TriglyceridesJournal of Biological Chemistry,
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54.Li, H., et alHeparin Cofactor II Inhibits Arterial Thrombosis After Endothelial InjuryJournal of Clinical Investigation,
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55.Chen, Z., et alHypobetalipoproteinemic Mice with a Targeted Apolipoprotein (Apo) B-27.6-specifying MutationJournal of Biological Chemistry,
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56.Circolo, A., et alGenetic Disruption of the Murine Complement C3 Promoter Region Generates Dificient Mice with Extrahepatic Expression of C3 mRNAImmunopharmacology,
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57.Shih. D.M., et alMice Lacking Serum Paraoxonase are Susceptible to Organophosphate Toxicity and AtherosclerosisNature,
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58.Sakai, N., et alTargeted Disruption of the Mouse Lecithin: Cholesterol Acyltransferase (LCAT) GeneJournal of Biological Chemistry,
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59.Korhonen, V., et alSpermine Deficiency Resulting from Targeted Disruption of the Spermine Synthase Gene in Embryonic Stem Cells Leads to Enhanced Sensitivity to Antiproliferative DrugsMolecular Pharmacology,
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60.Esteban, L.M., et alTargeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and DevelopmentMolecular and Cellular Biology,
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61.Kaufman, R.M., et alLack of Neighborhood Effects From a Transcriptionally Active Phosphoglycerate Kinase-neo Cassette Located Between the Murine B-major and B-minor Globin GenesBlood,
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62.D'Agostino, D., et alDecreased Postnatal Survival and Altered Body Weight Regulation in Procolipase-deficient MiceJournal of Biological Chemistry,
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63.Lagutina, I., et alPax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop TumorsMolecular and Cellular Biology,
Vol. 22, No. 20, pp. 7204 - 7216, 2002
64.Yu, K., et alConditional Inactivation of FGF Receptor 2 Reveals an Essential Role for FGF Signaling in the Regulation of Osteoblast Function and Bone GrowthDevelopment,
Vol. 130, pp. 3063 - 3074, 2003
66.Coste, S.C., et alAbnormal Adaptations to Stress and Impaired Cardiovascular Function in Mice Lacking Corticotropin-releasing Hormone Receptor-2Nature Genetics,
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67.He, J., et alTargeted Disruption of Dkc1, the Gene Mutated in X-linked Dyskeratosis Congenita, Causes Embryonic Lethality in MiceOncogene,
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68.Lu, Z.H., et alLong Targeting Arms Do Not Increase the Efficiency of Homologous Recombination in the B-globin Locus of Murine Embryonic Stem CellsBlood,
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69.Niiranen, K., et alTargeted Disruption of spermidine/Spermine N1-Acetyltransferase Gene in Mouse Embryonic Stem Cells: Effects on Polyamine Homeostasis and Sensitivity to Polyamine AnaloguesJournal of Biological Chemistry,
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70.Kiefer, S.M., et Expression of a Truncated Sall 1 Transcriptional Repressor is Responsible for Townes-Brocks Syndrome Birth DefectsHuman Molecular Genetics,
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71.Ranger, A.M., et alBad-deficient Mice Develop Diffuse Large B Cell LymphomaProc. Natl. Acad. Sci. USA,
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72.Crestani, F., et alTrace Fear Conditioning Involves Hippocampal alpha5 GABAA ReceptorsProc. Natl. Acad. Sci. USA,
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73.Enomoto, H., et alRET Signaling is Essential for Migration, Axonal Growth and Axon Guidance of Developing Sympathetic Neurons Development,
Vol. 128, pp. 3963 - 3974, 2001
74.Ivkovic, S., et alConnective Tissue Growth Factor Coordinates Chondrogenesis and Angiogenesis During Skeletal DevelopmentDevelopment,
Vol. 130, pp. 2779 - 2791, 2003
75.Narducci, M. G., et alTCL1 Participates in Early Embryonic Development and is Overexpressed in Human SeminomasProc. Natl. Acad. Sci. USA,
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76.Brown, L.J., et alNormal Thyroid Thermogenesis but Reduced Viability and Adiposity in Mice Lacking the Mitochondrial Glycerol Phosphate DehydrogenaseJournal of Biological Chemistry,
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77.Rokosh, D.G., et alKnockout of the alpha1A/C-adrenergic Receptor Subtype: The alpha1A/C is Expressed in Resistance Arteries and is Required to Maintain Arterial Blood PressureProc. Natl. Acad. Sci. USA,
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78.Luo, Y., et alMice Deficient in BACE1, the Alzheimer's Beta-secretase, have Normal Phenotype and Abolished Beta-amyloid GenerationNature Neuroscience,
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79.Zhang, N., et alA Dominant-negative Pleiotrophin Mutant Introduced by Homologous Recombination Leads to Germ-cell Apoptosis in Male MiceProc. Natl. Acad. Sci. USA,
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80.Westervelt, R., et alHigh-penetrance Mouse Model of Acute Promyelocytic Leukemia with Very Low Levels of PML-RARalpha ExpressionBlood,
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81.Grenda, D.S., et alMice Expressing a Neutrophil Elastase Mutation Derived from Patients with Severe Congenital Neutropenia Have Normal GranulopoiesisBlood,
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82.Newberry, E.P., et alDecreased Hepatic Triglyceride Accumulation and Altered Fatty Acid Uptake in Mice with Deletion of the Liver Fatty Acid-binding Protein GeneJournal of Biological Chemistry ,
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83.Shapiro, S.D., et alNeutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in MiceAmerican Journal of Pathology,
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84.Blaeser, F., et alTargeted Inactivation of the IL-4 Receptor alpha Chain I4R Motif Promotes Allergic Airway InflammationJournal of Experimental Medicine ,
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85.Fenske, T.S., et alStem Cell Expression of the AML1/ETO Fusion Protein Induces a Myeloproliferative Disorder in MiceProc. Natl. Acad. Sci. USA ,
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86.Krempler, A., et alGeneration of a Conditional Knockout Allele for the Janus Kinase 2 (Jak2) Gene in MiceGenesis,
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87.Yang, X., et alNotch Activation Induces Apoptosis in Neural Progenitor Cells Through a p53-Dependent Pathway Developmental Biology ,
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88.Ondr, J.K., et alCharacterization of Murine Cathepsin W and Its Role in Cell-Mediated Cytotoxicity Journal of Biological Chemistry ,
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89.Hadland, B. K., et alA Requirement for Notch 1 Distinguishes 2 Phases of Definitive Hematopoieses During DevelopmentBlood,
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90.Revell, P.A., et alGranzyme B and the Downstream Granzymes C and/or F are Important for Cytotoxic Lymphocyte FunctionsJournal of Immunology ,
Vol. 174, No. 4, pp. 2124-2131, February 15, 2005
91.Leone, T. C., et alPGC-1alpha Deficiency Causes Multi-system Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic SteatosisPLoS Biology ,
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92.Lu, Z. H., et alYB-1 is Important for Lte-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence Molecular and Cellular Biology ,
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93.Lin, W., et alAllergic Dysregulation and Hyperimmunoglobulinemia E in Foxp3 Mutant Mice Journal of Allergy and Clinical Immunology,
Vol. 116, No. 5, pp. 1106- 1115, November, 2005
94.Lu, Z., et alCold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions During Murine EmbryogenesisMolecular and Cellular Biology ,
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95.Wang, Y., et alEpimorphin -/- Mice Have Increased Intestinal Growth, Decreased Susceptibility to Dextran Sodium Sulfate Colitis, and Impaired SpermatogenesisJournal of Clinical Investigation ,
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96.Friend, L.D., et alA Dose-dependent Requirement for the Proline Motif of CD28 in Cellular and Humoral Immunity Revealed by a Targeted Knockin MutantJournal of Experimental Medicine ,
Vol. 203, No. 9, pp. 2121-2133, September 4, 2006
97.Xu, J., et alNormal Lung Development in RAIG1-Deficient Mice Despite Unique Lung Epithelium-Specific ExpressionAmerican Journal of Respiratory Cell and Molecular Biology ,
Vol.32, pp.381-387, January 27, 2005
98.Blaeser, F., et alLong Term Memory Deficits in Pavlovian Fear Conditioning in CaMKK-alpha Deficient MiceMolecular and Cellular Biology, Vol. 26., No. 23, pp. 9105 - 9115, December, 2006
99.Krishnamurthy, K., et alCeramide Regulate Atypical PKCz/l-mediated Cell Polarity in Primitive Ectoderm Cells: A Novel Function of Sphingolipids in MorphogenesisJournal of Biological Chemistry, Vol. 282, No. 5, pp. 3379-3390, February 2, 2007
100.Lin, W., et alRegulatory T Cell Development in the Absence of Functional Foxp3Nature Immunology, (corrected online) February 18, 2007
101.Haribhai, D., et alRegulatory T Cells Dynamically Control the Primary Immune Response to Foreign AntigenJournal of Immunology, Vol. 178, No. 5, pp. 2961-2972, March 1, 2007